Rocca, The organization of intrinsic brain activity differs between genders: A restingstate fMRI study in a large cohort of young healthy subjects, Human Brain Mapping, 34, 6, (1330-1343), (2012). These results demonstrated the neurocognitive correlates of resting BEN in DMN/ECN and suggest resting BEN in DMN/ECN as a potential proxy of the latent functional reserve that facilitates general brain functionality and may be enhanced by education. Massimo Filippi, Paola Valsasina, Paolo Misci, Andrea Falini, Giancarlo Comi and Maria A. While BEN in DMN/ECN increases with age, it decreases with education years. Our results unanimously highlighted two brain circuits: the default mode network (DMN) and executive control network (ECN) through their negative associations of BEN to general functionality, which is independent of age and sex. To address this standing question and to test a novel hypothesis that resting BEN reflects a latent functional reserve through the link to general functionality, we mapped resting BEN of 862 young adults and comprehensively examined its associations to neurocognitions using data from the Human Connectome Project (HCP). While BEN mapping results have shown sensitivity to neuromodulations or disease conditions, the underlying neuromechanisms especially the associations of BEN or LRTC to neurocognition still remain unclear. The long-range temporal coherence (LRTC) can be characterized by resting state fMRI (rsfMRI)-based brain entropy (BEN) mapping. Here specialization was explored using fMRI by examining the degree to which brain networks preferentially interact with ipsilateral as opposed to contralateral networks. nique, resting-state functional magnetic resonance imaging (rs-fMRI) has been discussed as a functional imaging alternative for FDG-PET (Teipel et al., 2015).
The latent reserve if it exists may be reflected by the profound long-range fluctuations of resting brain activity. The human brain demonstrates functional specialization, including strong hemispheric asymmetries. Resting state brain activity consumes most of brain energy, likely creating and maintaining a reserve of general brain functionality.